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Unlike transitions which are limited to two mutation pairs, recruitment events were observed for every mutational class (Table 3 and Figure 2).
However, the numbers of dinucleotides and indels is relatively small and it is therefore unclear if these two mutation classes will keep their current Signature associations or segregate into independent mutational signatures when many more cancer genomes are analyzed.
Two mutation sites, Glu110Ala and Glu134Ala, were obtained in SBA.
In order to improve the efficiency of the common GA applied to multi-site land use allocation, two crossover steps and two mutation operations were designed.
For the mutations involving more than two mutation sites where the correlation between FoldX and experimental data vanishes, the profile-based calculation retains a strong correlation with the experimental measurements.
A panel of Mycobacterium tuberculosis isolates containing 13 different rpoB genotypes, two mutation genotypes within codon 315 of katG and one mutation genotypes at inhA was used to validate the microarray.
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Only two mutation-positive families were missed.
Heidenreich et al. (Risk Anal 1997 17 391 399) considered parameter identifiability in the context of the two-mutation cancer model and demonstrated that combinations of all but two of the model parameters are identifiable.
The most likely two-mutation model identified three haplotype risk backgrounds, corresponding to H2 and two subsets of H1 (Fig. 2).
Since viruses mutate fast, a two-mutation step is not such a big hurdle.
This result generalizes previously derived results of Heidenreich and others [15], [16] relating to the two-mutation model.
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