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The phrase 'two major problems' is correct and usable in written English.
You could use it to describe a situation or challenge that has two major components. For example, you could say, "Facing homelessness and poverty are two major problems faced by families in the inner city."
Exact(60)
There are two major problems.
Skeptics cite two major problems with the race for biotech.
At very best there are two major problems with ideology.
There are two major problems with Lehr's argument.
There were two major problems, which were in fact related.
There are at least two major problems, however.
But how is this to be done, given the existence of two major problems?
Contemplating treatment seems impossible: I can't do two major problems at once.
Two major problems had to be overcome for rural communal life to flower.
Among their parents, two major problems are unemployment and domestic violence.
It all creates a dreamy cinematic excitement, but there are two major problems.
More suggestions(16)
two main problems
two enormous problems
two major bottlenecks
two major inconveniences
two primary problems
two major challenges
two substantial problems
two major malfunctions
two major failures
two principal problems
two major disruptions
two major errors
two major constraints
two major question
two major problem
two significant problems
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com