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Given these two main methodological limitations, as common as they are in the literature, the above results should be taken as an upper bound of the probable outcomes.
With our set-up we could solve two main methodological problems of studying consequences of dispersal, randomization and detectability of free-living individuals.
Two main methodological differences might explain this discrepancy.
There are two main methodological strategies for probing the metabolome: targeted and untargeted (global) methods [2,7].
There is an ongoing theoretical debate in the bioethics literature concerning the relative merits of the two main methodological approaches: principalism and casuistry.
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Such approach faces three main methodological challenges.
In that literature, three main methodological approaches have been adopted — econometric studies, surveys and case studies.
Little and Rubin (1987, 2002) provide a comprehensive overview of statistical analysis with missing data and distinguish four main methodological schools in addressing missing-value issues in statistics.
We focused on three main methodological disparities; 1) one vs. two growth cycles, 2) flow cytometry vs. pLDH assessment of parasitemia, and 3) dialysis vs. no dialysis of plasma.
When undertaking the review, three main methodological weaknesses of this research area became apparent.
As a result of these three main methodological differences, UNAIDS does not necessarily support the HIV/AIDS mortality estimates published in the GBD 2010 study.
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