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A two-centred pragmatic randomised controlled trial of two interventions of postnatal support.
Exclusion of any interaction between the two interventions of the ADVANCE trial would have required a sample size 4 times as large to be adequately powered (20).
The aim of this study is to test two interventions of proven efficacy, a hand hygiene (HH) improvement campaign and an extensive central venous catheter (CVC) bundle, in reducing CVC-related bloodstream infection (CRBSI).
The method enables 'direct' evidence (i.e. evidence from studies directly comparing two interventions of interest) and 'indirect' evidence (i.e. evidence from studies that do not compare the two interventions directly) to be pooled under the assumption of evidence consistency [ 24].
The PROHIBIT study aimed at inventorying and analysing national and local infection prevention activities in Europe and to test two interventions of proven efficacy in central venous catheter (CVC) bloodstream infection (CRBSI) reduction: a multimodal CVC bundle and a multimodal hand hygiene (HH) improvement strategy.
Based on previous research that reported a standard deviation of 20.93 for a paired difference in mean compression rates, 16 we estimated that we needed 140 participants to detect a mean paired difference between any two interventions of five compressions per minute with a power of 0.80 and an α of 0.05.
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The effectiveness of two interventions to increase the use of multivitamins among women of childbearing ages was evaluated.
All-cause mortality was reported in 17 trials, covering all the eight interventions of interest.
Three interventions, of low-to-moderate risk of bias, had statistically significant results on at least one outcome measure.
Three interventions, of low-to-moderate risk of bias, had a statistically significant advantage over a comparison on at least one outcome measure.
This study evaluated the impact of three interventions on uptake of the guaiac faecal occult blood test (gFOBT) in Greater London.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com