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However, anticipating this request of the reviewers, we now also split the data in two independent halves and processed it separately.
To confirm that we had sampled conformational space sufficiently to reach model convergence, we compared two independent halves of the solutions to each other and to the entire set, showing they were all similar to one another.
The resolution was estimated based on the gold-standard FSC = 0.143 criterion (Scheres and Chen, 2012) by dividing the data in two independent halves and refining them iteratively against the cryoET model low pass filtered to 50 Å resolution.
(D ) FSC curves of the final model vs the complete engaged map (black); of a model refined in the first of two independent halves of the map (red); and of that model vs the independent second map (blue).
The resolution was estimated based on the gold-standard FSC = 0.143 criterion (Scheres and Chen, 2012) by dividing the data in two independent halves and refining them iteratively against the angular reconstitution model low pass filtered to 50 Å resolution.
Cross-comparisons between two independent halves of patient dataset revealed that subnetworks are good at distinguishing T-ALL patients from healthy individuals, regardless of the dataset in which they are found.
Similar(53)
As a result of two independent computations on raw data halves, two populations (A and B), consisting of 333 and 315 haplotypes respectively, were obtained.
Songbirds, and probably other birds, are able to control the right and left halves of the syrinx separately, thus singing with two independent voices.
These may represent two independent polypeptides (such as two parts of a heterodimer), or may have originally been halves of a single protein that underwent a fission event to become two polypeptides.
Two independent reasons [why].
One of two halves, of two captains to 100 Tests.
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