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Among patients with diabetes in urban slum communities in Nairobi the odds for hypertension were two fold, resulting in 45.5 % of patients with diabetes being hypertensive.
Further increases in the injected QD dose by three fold resulted in detectable fluorescence signals in the rat brain [149, 150].
These results were more or less same to the previous five fold results.
In the setting S4, we used a CV approach, in which both the drugs and the targets were partitioned into three folds, resulting in 9-fold combinations (3 × 3-fold CV).
The two subunits of dhMtb-BirA have structural differences in their loops and defy the expected two fold symmetry resulting in an asymmetric dimer where, subunit A can be considered a representation of the active ligand bound conformation of BirA and subunit B is more an icon of apo BirA with disordered loops.
This protocol was repeated three fold and results on one experiment are shown.
This has been found to increase the speed of PROCOV by at least three fold (see results below).
The implications of the results are two fold.
But unlike the K1 models where variation of Sig + kinases' concentration resulted in two fold decrease in robustness as compared to kinases' concentration variation with constant Sig (Compare Figure 2A and 2C), the K2 models showed very little change in MK-PP robustness while subjected to such perturbations (Compare Figure 3A and 3C; Figure 3B and 3D).
The result is a two fold decrease in the efflux R12 and PC concentration (see Figure 5).
In addition, mutation of the Fbc complex, which is predicted to redirect flux through the Qox pathway, results in a two fold increase in doubling time experimentally, which is almost identical to the predictions of iRsp1095 (see results and [ 56]).
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