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Patterns of divergence between sibling species, extending the time scale of analysis, showed remarkable heterogeneity among functional regions of gambicin across all three species pairs, with over ten fold reduced divergence in coding as opposed to NC regions.

Because polymorphism in the coding regions was not exhausted as our data showed, purifying selection cannot explain the ten fold reduced divergence in coding as opposed to NC regions at gambicin.

For an input size of 1000 samples TERA achieves comparable accuracy to TreeFix-DTL, but with a seven fold reduced mean runtime.

The proposed approach improves upon the existing literature in two folds: reduce the computational burden and provide an algorithmic procedure that would seamlessly connect the state estimation and parameter estimation parts of the observer design.

When activated under Th1-polarizing conditions, Tbx21-deficient CD4+ T cells showed a four- to six-fold reduced induction of miR-148a expression (Fig. 5B).

Specifically, the substitution of a methionine (Met) for a valine (Val) at position 158 results in three- to four-fold reduced activity of the COMT enzyme due to reduced protein stability [ 13- 15].

Four human H5N1 strains had eight-fold reduced in-vitro susceptibility to oseltamivir as compared to clade 1 viruses.

Three of 30 clade 2.3.4 viruses contained a I223T mutation and showed 7-fold reduced inhibition by oseltamivir.

Regulatory T cells were about two-fold reduced in number in the thymuses and spleens of Lck and Lck/Fyn mice compared to control or Fyn mice (Figure 3AB).

The results show that the histone protein content is about two-fold reduced in His C mutant embryos.

While the precise nature of this role is not known, the impact of high serum LHCGR in pregnancy could be two-fold: reduced hCG bioactivity and aberrant systemic vasculo-endothelial and immune activation.

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