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The fact that this IgM is therapeutic in two disparate models (viral and genetic) implies that neuronal protection occurs by a broad mechanism possibly through an indirect mechanism involving immune cells that amplify the single dose of IgM.
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We therefore sought to address this question for two disparate model systems from the class of small ribozymes, the hepatitis delta virus (HDV) and Varkud Satellite (VS) ribozymes.
We describe here a protocol that achieves >95% chemical and conformational purity within an hour of transcription for two disparate model RNAs.
For two disparate model systems, the Varkud satellite (VS) and hepatitis delta virus (HDV) ribozymes, we achieve >95% conformational purity within one hour of enzymatic transcription, without the need for any folding chaperones.
But while analysts praised the deal as one that would help cement Webvan's market leadership, investors focused on the uncertainties of melding two disparate business models and technology bases, sending shares in both companies down.
Despite the conserved usage of patterning mechanisms and gene regulatory networks that act to generate specific spinal cord progenitors, there now exists two seemingly disparate models to account for their action.
Chain convergence was assessed by running the model for two disparate sets of initials values, and by then checking that the Brooks-Gelman-Rubin diagnostic converges to 1.0.
Proceeding chronologically, for each epoch, the measurements of lead in the body are presented along with mathematical models in an attempt to trace the convergence of observations from two disparate fields--occupational medicine and radiologic health--into some unified models.
This paper proposes a framework to enable fuller integration of otherwise disparate models into integrated models in the federated environment by enabling two critical concepts – deferred reference and an automatic object snap-in.
To better understand this driver, we modeled the effects of urbanization on three regulating and provisioning ecosystem services in two disparate watersheds in Florida, USA.
(The artist enjoyed depicting two disparate objects).
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