Suggestions(1)
Exact(16)
Distinct pKa values of 6.3 and 5.35 are assigned to the first and second protonation of the Asp pair; together they represent an energetic difference of 5 kcal/mol relative to the protonation of two Asp residues with unperturbed pKa values.
Two ASP Phs worked routinely as designated ICU Phms.
GMP contains two Asp, seven or eight Glu (depending on genetic variants), one phosphorylated Ser, and three Lys residues.
Their catalytic centre is formed by two Asp residues that activate a water molecule, and this event mediates the nucleophilic attack on the peptide bond [ 14].
All the OsRR proteins also contain the highly conserved Lys and two Asp residues (D-D-K) in the receiver domain (Fig. 1B, C).
These data show that the presence of two Asp residues decreases the rates of phosphorylation of S656 and S664 and increases that of S660.
Similar(44)
It is well known that protein kinases adopt two "Asp-Phe-Gly (DFG)" motifs: the active DFG-in conformation and inactive DFG-out conformation at the activation loop [41].
On the basis of the findings, we designed, synthesized and evaluated two Asp-modified 111In-DTPA-conjugated octreotide derivatives, 111In-DTPA-Asp1-octreotide and 111In-DTPA-Asp0-d-Phe1-octreotide.
As CXCR3 is highly unusual among the chemokine receptor family in not possessing a glutamate at this position, we turned our attention to an aspartate in helix two, Asp-1122 63. Asp-1122 63
Although amino acid utilization is specific for individual cell lines, culture conditions, and biological products (Jayme 1991), we and others repeatedly found Asn (in six media), Ser (four), Tyr (three), and Asp (three) to be limiting (Chen et al. 2000; Altamirano et al. 2006; González-Leal et al. 2011; Jordan et al. 2013).
One ASP that primarily focuses on small businesses is privately held CenterBeam, an all-outsourced Internet protocol (IP) service provider.
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