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Here, we identified high confidence PML-RARα binding sites in an acute promyelocytic leukemia (APL) cell line and in two APL primary blasts.
Nineteen patients (48%) had at least two aPL determinations, 12 (63%) of them being positive (5 with IgG aCL plus LA, 4 with IgG aCL only, 2 with IgM aCL plus LA, and one with LA plus IgM plus IgGaCL), and only two of them had antiphospholipid syndrome.
Similar(58)
In addition, the favorable specificity of aPL testing by LIA could also be confirmed in this study revealing no significant difference for all ten aPL tested by LIA compared with the four consensus criteria aPL by ELISA.
Thirty-two Apatientsnts and ten iron deficiency anemia patients as control who attended Renji Hospital were enrolled in this study.
Saliva samples were collected from nine APL patients over three consecutive days.
In total, 108 saliva samples were collected from nine APL patients.
Among the 20 synthesized APLs, four (APL 6; N329S, APL 7; N329T, APL 12; G332APLAPL 13; G332V) significantly reduced IL-17 production by CD4+ T cells in the presence of hGPI325-339.
There was only one NHS demonstrating three aPL IgM antibodies (anti- β2 GPI, anti-CL, and anti-PS) simultaneously in the MLDA.
Testing type A sera revealed five APL (36Ala, 37Ala, 39Ala, 43Ala and 49Ala) that failed to bind the sera (Fig. 1F).
Furthermore, we determined if the patients were ever positive in all three aPL tests (aCL (IgM and IgG), anti-β2gGP-1 (IgG) and LA).
By comparing the various GEPs obtained, a clear difference was seen between the three APL cases to all other cases in expression of various transcripts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com