There was limited variation on some of our predictor variables such as absenteeism, burnout and turnover, which may have limited the statistical power to detect significant effects.
This suggests that high oxidative fibers have a relatively high rate of protein turnover, which may limit hypertrophy in these fibers.
Bfl-1 and Mcl-1 in particular are subject to constitutive ubiquitination and proteasomal turnover, which may affect their antiapoptotic capability.
In addition, staff at referral community agencies that are aware of and engaged with the study may also turnover, which may have a bearing on the quality of service provision.
Aging decreases macromolecular turnover which may underlie the age-related accumulation of oxidative damage, while CR is thought to extend lifespan by reducing metabolic rate and lowering the production of toxic by-products of metabolism [ 29].
Among other possibilities, this observation suggests that, while there may exist a last common ancestor to the translation/transcription machinery, this was probably not so for the machineries leading to RNA turnover, which may have appeared independently on several occasions.
However, calculated clearance may be subject to errors because it does not take into account features such as muscular mass and turnover, which may influence creatinine concentrations in the serum [ 29].
The C57BL/6J strain (hereafter referred to as C57) has the highest basal TDO activity and a consequently lower serum-free and total [Trp], resulting in decreased cerebral serotonin (5-HT) synthesis and turnover, which may be related to its alcohol preference [ 20– 20].
