It was recently suggested that, in addition to deformation forces, microdamage plays an important role in regulating bone turnover and strength.
At 12 or 24 months, efficacy was mostly determined by BMD, bone turnover markers, muscle strength, and balance.
Indeed, the acute regulation of their protein level is a primary determinant of protein turnover and neurotransmission strength [ 40, 41].
Our model predicts a positive correlation between clonal age and neutrality indices; this is because as the rate of clonal turnover or the strength of Muller's ratchet increases, the average age of clones decreases [ 13], and measured neutrality indices tend to have negative values.
Both type of drugs inhibit bone turnover, and thereby bone strength may be weaker as a result of treatment.
In a recent study, the authors evaluated the effects of odanacatib on bone turnover, BMD and bone strength in the lumbar spines of oestrogen-deficient, skeletally mature rhesus monkeys.
74 Two related studies in OVX monkeys that evaluated the effects of ODN on bone turnover, BMD, and bone strength had findings that were common with conventional antiresorptives and other findings that were different.
Although we did not perform bone-biopsies, which are the gold standard in assessing bone turnover, one of the strengths of the study is the characterization of markers of bone turnover.
The present study examined the effect of the highly potent nitrogen-containing bisphosphonate, minodronic acid (ONO-5920/YM529), on bone mineral density (BMD), bone turnover, bone histomorphometry and bone strength in ovariectomized (OVX) rats.
This study examined the effect of the highly potent nitrogen-containing bisphosphonate, minodronic acid (ONO-5920/YM529), on bone mineral density (BMD), bone turnover, bone microarchitecture and bone strength in ovariectomized (OVX) cynomolgus monkeys.
