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At this point we cannot tell if the three informative AGEs play a causative role in DN progression or reflect turnover of increased tissue stores of these AGEs, but considering that there is substantial evidence that AGEs can play a pathogenic role in vascular damage (32– 34), the former is possible.
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In health, its principal role is to protect against excessive bone turnover during times of increased need by attenuating the activity of osteoclasts [ 25].
An increase in the turnover of Mdm2_mRNA increases the responsiveness of the system, resulting in a more rapid increase in Mdm2_mRNA and hence Mdm2 protein synthesis following DNA damage.
These data suggest the possibility of increased turnover cells of the gastrointestinal mucosa and inhibited DNA synthesis in several organs.
Unlike MPTP, deltamethrin did not decrease dopamine, although there was some evidence of increased turnover.
Given the perceived role of vitronectin in cancer, decreased vitronectin levels in serum might be a reflection of increased turnover rate of vitronectin by tumour cells.
Functional disturbances in EE include reduced absorption, increased turnover of intestinal cells, increased mucosal permeability, and generalized activation of the innate and adaptive immune system (29).
Focal uptake can represent other causes of increased bone turnover, such as degeneration, fractures in healing, or inflammation.
The quantities of increased NADH turnover resulting from the inactivation of PFL were about 11-fold higher than that of inactivation of NADH-dependent LDH.
Scintigraphy relies upon abnormal uptake of radio tracer in areas of increased bone turnover.
Paget's disease of the bone (PDB) is characterised by focal abnormalities of increased bone turnover.
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CEO of Professional Science Editing for Scientists @ prosciediting.com