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The recruitment of enolase by the RNA degradosome has been implicated in the turnover of certain transcripts, and it is mediated by a small segment of roughly a dozen residues that lie within a natively unstructured sub-domain of RNase E. Here, we present the crystal structure of enolase in complex with its recognition site from RNase E at 1.6 Å resolution.
Importantly, we demonstrated that proper turnover of certain key piRNA targets is essential for sperm formation.
Sequential turnover of certain cell cycle regulators, including cyclins and CKIs p21cip1/waf1 and p27kip1, are mediated by the 20S proteasome, which promotes proteolytic degradation through the ubiquitin/proteasome pathway.
Importantly, ectopic expression of piRNA-resistant forms of target genes in spermatids prevented the formation of sperms, suggesting that proper turnover of certain piRNA targets is essential for normal spermiogenesis.
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The impact of mRNA stability control on normal and malignant myelopoiesis has been less well characterized despite evidence that changes in turnover rates of certain mRNAs can dramatically affect cellular behavior (for review, [35]).
16 20 The elimination rate of fluorescein sodium essentially represents the bulk aqueous flow because the dye is hydrophilic; however, the turnover of a certain tear component may not parallel the bulk aqueous flow.
Although chondrocytes in this context do not normally divide, they are assumed to maintain the extracellular matrix (ECM) by low-turnover replacement of certain matrix proteins.
They also say that Mr. Orban's economic policies, which include new taxes on turnover for certain sectors of the economy, will deter foreign investors.
Hence, the rapid turnover of residents in certain locations is a risk factor for bedbug infestation.
The formation of isomerized aspartate (IsoAsp) within matrix proteins could also interfere with the normal turnover of cartilage as certain proteases, including matrix metalloproteinase-3 and some caspases, are unable to cleave their substrate if an IsoAsp is present in the target sequence [ 12].
Foetal growth restriction (FGR) is a pregnancy complication associated with aberrant trophoblast turnover and reduced activity of certain amino acid transporters, including the taurine transporter (TauT).
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