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Selections for enzymes can be performed indirectly (for binding of a transition-state analogue or mechanism-based inhibitor), and directly using either intramolecular single-turnover selections (e.g. with SELEX) or the normal (intermolecular, multiple turnover) mode of enzymatic reactions.
Finally, estimates of PAPS concentrations across a variety of tissues suggest that SULT1A1 reactivity will be highly tissue-dependent, and that the enzyme will function in its broadest specificity and highest turnover mode in tissues that experience the highest levels of xenobiotics.
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The improvement in hippocampal function is ultimately attributed by the reduction of plaque accumulation or turnover; nevertheless, other modes of action in AD are possible.
In healthy volunteers, the mode of cellular turnover was primarily apoptotic cell death.
In summary, we have demonstrated that in healthy volunteers, cellular turnover occurred primarily by the apoptotic mode of cell death.
Consistent with previous observations (Wang, 1985; Hotulainen et al, 2005; Nakagawa et al, 2006), these data supported a treadmilling mode of actin filament turnover in lamellipodia.
These observations revealed a novel relationship between the stability and expression level of a biological molecule, which may present an important action mode of miRNAs, "rapid production, rapid turnover, and slow production, slow turnover".
The above analysis has revealed a distinct mode of miRNA stability, "rapid production, rapid turnover; slow production, slow turnover".
This finding indicates that miRNA has a distinct action mode, which we called "rapid production, rapid turnover; slow production, slow turnover".
In summary, our analysis of equilibrium levels and dissociation rates in mouse ESCs revealed different modes of H3.3 deposition and turnover that pertain to their pluripotency.
Biofilm cells might simply have a slower turnover of proteins due to the biofilm growth mode, but further research is needed to determine this characteristic.
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