First, the regulation of translation or of protein turnover rate may cause the protein abundance to not be proportional to mRNA abundance.
"Our data indicate that low employee turnover at many companies may cause a lack of creativity, stale management and failure to adapt to changing times," he said.
Together, these studies suggest that mutations in either parkin or PINK1 may alter mitochondrial turnover, which in turn, may cause the accumulation of defective mitochondria and, ultimately, neurodegeneration in PD (for comprehensive reviews, [101,126 128].
Since there are numerous endosomal/lysosomal pathways, the loss of one protein would not necessarily result in massive disturbances but may limit the number of protein turnovers and recycling which may cause a "domino" effect by directly or indirectly disrupting downstream pathways during neural development.
Moreover, the apoptosis that is also induced may cause abnormal cell turnover and thereby skew the representation of different taste bud cell types, leading to the development of taste disorders [34].
Elevated cholesterol levels are atherogenic and can produce repeated mechanical, hemodynamic, and/or immunological injury and, as such, may cause augmented cell turnover and increased production of ROS in certain cells (32).
For post-menopausal women, high bone turnover may be caused by estrogen deficiency.
Indeed, business failure is all the more probable as the firm faces difficulties in selling its product which may cause a continuous decline in turnover as well as a decrease in profitability.
It may be involved in central inhibition of prostaglandin synthesis, or it may cause a decrease in serotonin turnover in the central nervous system [ 5, 7, 8].
