Interestingly, safranin-O staining is more uniformly distributed and aggrecan gene expression is higher in menisci from mature animals than from immature animals, suggesting that these regional variations in aggrecan density and turnover are dependent on developmental stage [ 3].
This further emphasizes that muscle ATP turnover rate is dependent on intracellular substrate supply and that ATP turnover rates are not limited by the presence of type 2 diabetes but respond to metabolic conditions.
This application on living cells can provide new insights into the receptor turnover, but is dependent on the applicability of primary fluorescent antibodies.
Similarly, there is a sustained elevation in SF turnover rates that is dependent on the frequency of stretch (Figure 5C).
Thus Mad3p turnover in G1 is dependent on Cdh1-APC/C activity and its own N-terminal KEN box (KEN30).
The turnover of chitin is dependent on hydrolysis, resulting in small oligosaccharide chains, which may become further accessible to different metabolic and biochemical processes.
They propose that, in healthy intestine, the turnover of ATG16L1 is dependent on basal caspase-3 activity; in the presence of T300A, however, the persistence of apoptotic stimuli enhances ATG16L1 cleavage, triggering cytokine production and inflammation [ 108].
