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Greater levels of C2C-HUSA and CTX-II in adolescents than in adults may reflect increased cartilage turnover in response to higher joint loading.
In contrast, shrub seedlings, and to a lesser extent pine seedlings, maintained higher pre-dawn moisture potentials (ψpd>−2.9) and greater phenological plasticity (fast turnover) in response to drought, contributing to greater growth and survival success.
Autophagy is an intracellular degradation pathway that functions in protein and organelle turnover in response to starvation and cellular stress.
We previously developed a biochemical assay using Xenopus laevis egg extract that recapitulates Axin and β-catenin turnover in response to addition of recombinant Wnt co-receptor (LRP6) [29].
Although the atrophic phenomenon at altitude has been described for decades, the underlying peripheral protein kinetics and mechanisms remain unresolved and only few human data on protein turnover in response to hypoxia exist.
This may be an example of a population turnover in response to extreme environmental conditions.
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BASCs represent one of several regional progenitor cell populations in the adult lung and are responsible for regeneration of bronchiolar and alveolar epithelium during homeostatic turnover and in response to injury [ 4, 36].
Normal mature hepatocytes and cholangiocytes stay in the G0 phase of the cell cycle, exhibit a quiescent phenotype and show minimal turnover, but in response to partial hepatectomy (PH), they can undergo cell proliferation to compensate for the lost cells, a process called liver regeneration.
During natural turnover and in response to injury, the airway basal cells function as stem/progenitor cells for the other airway cell types.
Because reports in nonhematopoietic cells have demonstrated that p21 transcript turnover changed in response to cellular stress, growth factors and differentiation stimuli, we posited that IL-3 induction of p21 could reflect mRNA stabilization.
Given the various degrees of mitochondrial protein turnover impairment in response to a deficit in either proteasom- associated factors or selective autophagy regulators, two theories attempt to pinpoint the pathways involved in mitophagy.
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