Sentence examples for turnover impairment from inspiring English sources

This challenging body of evidence prompted us to investigate whether, also in vivo, OxS might be an influencing factor for the bone turnover impairment underlying PO development.

Given the various degrees of mitochondrial protein turnover impairment in response to a deficit in either proteasom- associated factors or selective autophagy regulators, two theories attempt to pinpoint the pathways involved in mitophagy.

Strikingly, a combined treatment of CPTH6 with late-stage autophagy inhibitors, such as chloroquine and bafilomycin A1, demonstrates that under basal condition CPTH6 reduces autophagosome turnover through an impairment of their degradation pathway, rather than enhancing autophagosome formation, as confirmed by immunofluorescence experiments.

Employee turnover is increasing.

Quick inventory turnover.

The mitochondrial pathology in PINK1-deficient animals might be caused by an insufficient recruitment of Parkin followed by an impairment of mitochondrial turnover (Ref. 43).

Inhibition of autophagy led to accumulation of vesicles close to the endplates that contain bungarotoxin (BGT), further corroborating an impairment of AChR turnover and of endosome trafficking.

The stem cell dysfunction may induce the impairment of cell turnover, resulting in the disturbed functions of the brain and skeletal muscle in DM.

A decreased production of NO by the mitochondrial form of NOS (mtNOS) has been proposed as a cause of decreased mitochondrial biogenesis, resulting in impairment of cellular turnover, tissue regeneration (heart, brain, liver) and aging [ 11, 12].

It has been reported that autophagy is involved in collagen turnover [42], and that the impairment of autophagy induces the accumulation of procollagen aggregates in the endoplasmic reticulum [43].

It has been suggested that impairment in collagen turnover could be a component of the disease phenotype and that it appears as an early manifestation of sarcomere gene mutations, before the development of overt LV hypertrophy.