Because osteoclastic bone resorption and high bone turnover enhance tumor growth in bone [10], [11], we hypothesized that Arf loss in Tax mice would accelerate the growth and progression of tumors in the bone.
Blocking MVB turnover enhanced, whereas blocking MVB maturation inhibited miRNA-mediated target mRNA silencing, indicating that MVBs and GW bodies are functionally involved in miRNA-mediated RNA silencing.
The increase in autophagic turnover could enhance mitochondrial turnover and biogenesis, and, consequently, decrease ROS production.
Addition of epoxomicin or 3-MA has no effect on the turnover rate of mHDx-1 in the presence of Happ1, reinforcing the conclusion that Happ1 does not increase mHDx-1 turnover by enhancing proteasome or macroautophagy function.
ACT1 redirects uncoupled Cx43 hemichannels into gap junctions, thereby reducing gap junction turnover and enhancing gap junction aggregation, without effecting Cx43 protein levels [ 33, 34].
SHIP2 also promotes cancer cell proliferation and metastasis by preventing epidermal growth factor receptor (EGFR) turnover and enhancing EGF-induced Akt activation [ 12, 21].
Milk IGFs may support nutrient transfer to the young by increasing mucosal cell turnover and enhancing villus growth of the newborn's gastrointestinal tract [ 51, 52].
Long-term, sustained CNVR programmes in Rajasthan have successfully eliminated rabies as well as reducing dog population turnover, therefore enhancing persistence of vaccinated animals in the community [ 15, 21, 29].
Based on pre-clinical studies, strontium ranelate is believed to exert an uncoupling effect on bone turnover by enhancing bone formation at the same time that it suppresses bone resorption (Marie et al 1993).
In transgenic glands, before lesion development, epithelial cell turnover was enhanced overall compared with nontransgenic glands, indicating that aberrant cell turnover in normal epithelia may contribute to tumorigenesis.
