Furthermore, we also found that the lack of SUMO conjugation to FLS2K/R-GFP neither correlated with anomalies in sub-cellular localization (Supplementary Fig. 3), nor with protein turnover rate differences between FLS2 and FLS2K/R (Supplementary Fig. 4 and Supplementary Fig. 24).
We believe an important part of this apparent contradiction with previously published turnover data relates to differences between acute, subacute, and chronic CR treatments.
Hence, we suggest the need for more rigorous investigations, e.g., those using transient kinetics, on the potential differences between the turnover cycles of the caveolar and noncaveolar preparations, and the possible physiological implications of such differences.
After eight weeks, blood and urine tests for bone turnover showed no difference between the two groups.
In turn, these domains seem to be necessary for regulating protein turnover and help to establish functional differences between KLF6 and KLF6-SV1, whave have both been shown to play important roles in cancer initiation, progression and survival and for predicting outcome.
Strong evidence exists for differences in joint tissue turnover for different joint systems, best exemplified by differences between knees and ankles [34].
Thus, investigating differences between biomarkers of cartilage turnover in adolescent and adult athletes could provide insights into how these biomarkers reflect different cartilage changes and adaptations to exercise in these two populations.
To further infer the possible mechanisms behind the likely ecological differences between species that drive species turnover in the community, we explored the parametric form of zeta diversity decline.
The differences between the residues required for the turnover of these substrates may reflect differences in the molecular environment of the O-GlcNAc site(s) on these proteins/peptides, and could tune O-GlcNAc cycling rates.
This suggests that mechanisms driving species-specific occupancies (i.e. ecological differences between species) dictate the multi-site species turnover in the community.
