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The authors recognized several confounding factors that might have influenced their results (i.e., staff turnover, differences in patients characteristics, etc).
However, the disease course in mice was more slowly progressive than humans, suggesting substrate turnover differences between mice and humans as has been observed in Gaucher disease point mutation models in mice (38).
The reason for this is not clear, but could be due to differences in the rate of plasma membrane turnover, differences in other essential biological functions requiring N-myristoylation or due to differences in cellular pharmacokinetics of drug uptake or efflux.
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We agree that the gene body turnover difference is small in absolute magnitude, which emphasizes that the biggest effect by far of mammalian Chd1 is at promoter proximal nucleosomes.
We reasoned that if CSC, like tissue progenitor cells, had a reduced turnover, then differences in proliferation would allow us to segregate fractions enriched for CSC.
On longer timescales, population turnover generates differences in individual age and experience and there is a shift from collective exploration to cultural inheritance, where behavior is inherited over generations.
Turnover results from differences in how species respond to climate and soil gradients.
When comparing the mean job satisfaction and motivation scores and subscores according to turnover intention, significant differences (P < 0.05) indicated that job satisfaction and motivation was lower for health workers having turnover intentions than for those not having turnover intentions.
Here, we show that none of these parameters were correlated with biochemical markers of bone turnover and no differences in levels were noted between the two BMD groups, indicating that the serum levels of HDL cholesterol and triglyceride may not be directly related to bone metabolism.
The dynamics of inositol phosphate accumulation following GnRH receptor activation were similar in the different cell lines but differences in turnover following removal of inositol phosphatase inhibition (LiCl wash off) occurred according to the cell line.
Ingram contributed 21 points and Hill pitched in with 9 points, 6 assists and just one turnover, a marked difference from the last game, when they combined for 12 turnovers.
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