The authors recognized several confounding factors that might have influenced their results (i.e., staff turnover, differences in patients characteristics, etc).
However, the disease course in mice was more slowly progressive than humans, suggesting substrate turnover differences between mice and humans as has been observed in Gaucher disease point mutation models in mice (38).
The reason for this is not clear, but could be due to differences in the rate of plasma membrane turnover, differences in other essential biological functions requiring N-myristoylation or due to differences in cellular pharmacokinetics of drug uptake or efflux.
We reasoned that if CSC, like tissue progenitor cells, had a reduced turnover, then differences in proliferation would allow us to segregate fractions enriched for CSC.
On longer timescales, population turnover generates differences in individual age and experience and there is a shift from collective exploration to cultural inheritance, where behavior is inherited over generations.
Ingram contributed 21 points and Hill pitched in with 9 points, 6 assists and just one turnover, a marked difference from the last game, when they combined for 12 turnovers.
When including a multiplicative term interacting the existence of payback clauses with turnover, no significant difference emerges in the relationship of turnover and CVT spending between firms applying payback clauses and firms not applying payback clauses (Table 2, column 6).
Conversely, rats in the HFHC diet group showed slightly lower C-GSH than the control group (0.86 ± 0.18 mmol/L), indicating a lower GSH turnover, though this difference was not statistically significant.
The PP diet induced tissue specific changes in gene expression, with the mid intestine showing activation of the adaptive immune response indicating potential for hypersensitivity and an increase in protein turnover, although no difference in histopathological changes were observed in the proximate, mid or distal intestine.
Thus, PFT substrate specificities reflect differences in catalytic turnover rate rather than differences in binding affinity.
