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Bulk analysis of overall protein labeling level is skewed by the synthesis rate of a few highly abundant structural proteins, whereas in our study and the study by Price et al., measurements of average protein turnover changes in large numbers of individual proteins are not weighted toward the most abundant structural proteins.
Once the target allocation had been set in this way, it would be for the primary care trust to decide if and when to make further adjustments to account for issues such as population turnover, changes in list size, new practices, "distance from target," and pace of change to the target allocation.
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Because reports in nonhematopoietic cells have demonstrated that p21 transcript turnover changed in response to cellular stress, growth factors and differentiation stimuli, we posited that IL-3 induction of p21 could reflect mRNA stabilization.
However, the use of species richness as the sole basis for quantifying changes in biological diversity is limited when there is species turnover (change in species composition), a large change in species abundance, or a difference in sampling effort over space and time [6].
Although changes at the mRNA level cannot, of course, be directly extrapolated to metabolic adaptations, we show that the expression of genes involved in metabolism and cell turnover changed in a highly significant, coordinated manner, with a remarkably discontinuous transition between short-term and prolonged fasting.
It is noteworthy that rabbits consuming a high-fat diet ad libitum experience haemodynamic, neurohumoral and increased lipid turnover changes similar to those observed in obese humans [ 26].
Bone turnover marker changes in response to physical activity are well documented.
To examine the relationships between various components of nursing home staffing (total staffing levels and staff mix, staff turnover, and changes in staffing patterns) to an important measure of quality, risk-adjusted rates of pressure ulcer development.
Population structures affect convergence in aging through cohort turnover and changes in the size of the non-working-age population.
Staff turnover and changes in administrative leadership limits their influence over time.
This observation is somewhat surprising because this geological period has witnessed dramatic climate perturbations [12], potentially increasing the rate of community turnover through changes in species' distribution ranges and extinction [13] [15].
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