Sentence examples for turnover attenuation from inspiring English sources

The clinical impact of serum phosphorous reduction on the relevant outcome is far from being established, especially in light of the recently published results of the EVOLVE trial [ 2], and future studies should address whether high-bone turnover attenuation increases survival among CKD-5D subjects.

In the kidneys, Gal 3 protects renal tubules from chronic injury by limiting apoptosis and it may be an important factor in matrix turnover and fibrosis attenuation [ 30].

Furthermore, the rapid turnover of U6atac after attenuation of either RNA polymerases II or III makes the minor spliceosome a real time sensor of transcriptional activity in cells.

Obviously, the two explanations for AR-mediated protection against Lef1 haploinsufficiency – molecular interaction with the Wnt pathway and attenuation of bone turnover – are not mutually exclusive.

However, 6 weeks of CAFG treatment to OVx group significantly lowered back the levels of this marker to ∼30%, indicating attenuation of bone turnover and thus resorption.

These data further substantiate the CPI-dependent attenuation of EGFR turnover in the Western blot assay, as the presence of EGFR on early endosomes and adequate induction of signaling shortly following ligand addition rule out the possibility that preincubation with CPI interferes with receptor internalization or alternatively abolishes receptor access to the plasma membrane.

This decline in fracture risk at the spine was of a magnitude similar to that seen with more potent antiresorptive agents such as the aminobisphosphonates and emphasized the importance of attenuation of bone turnover, in addition to effects on BMD, for fracture risk reduction [ 81, 82].

The consequence of activation of PDE3B is expected to be a faster turnover of cAMP and essentially an attenuation of insulin secretion as cAMP has an established role as a potentiator of insulin secretion through PKA-dependent and PKA-independent mechanisms.

Once the model was established, a relatively short (7 days) treatment with OPG-Fc did not alter synovial inflammation, suggesting that the effects of pre-emptive OPG-Fc on synovitis may be indirect for example, via an attenuation of subchondral bone turnover or cartilage pathology.

Attenuation of the excessive ECM turnover by aldosterone antagonism was suggested as one of the mechanisms underlying its beneficial effects in systolic heart failure [ 10, 11].

In this work, we harness the previously presented computational technique, flux-sum analysis [ 22], to identify metabolite targets that will "force" the overproduction of desirable by-products or the reduction in formation of undesirable metabolites upon the attenuation or intensification of metabolite turnover, also known as "flux-sum".