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This polarity is also manifested in the varying densities of phospho-paxillin, which affect FA assembly, turnover and stability [42].
To further ensure reliability of analyses, all measurements of spine turnover and stability were carried out blind by two experimenters.
The measures of density, turnover and stability were carried out by analyzing all protrusions, i.e. filopodia and spines.
Furthermore, the regulatory mechanisms of the genome and proteome are complex and both turnover and stability of mRNA levels are important for translation of mRNA into protein [55].
This differential reduction of miRNAs in the KO cells may be due to different turnover and stability rates for each miRNA in multiple biogenesis pathways in different tissues [56], [57].
Interestingly, several of the RING E3s that were found in apicomplexan parasites are potentially involved in mRNA turnover and stability (PFI0470w in P. falciparum) or pre-mRNA maturation (PF14_0139 and PF14_0416 in P. falciparum, and 50.m03082 and 42.m00073 in T. gondii) [96].
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The produced nanocomposites, x%-Sb/C/palygorskite composites, exhibited higher turnover frequency and stability than Sb/C nanocomposites synthesized under the same condition but without palygroskite as support, which is attributed to a strong interactions between Sb nanoparticles and modified palygorskite.
Our study demonstrates that H3.3 turnover and nucleosome stability vary greatly across the chromatin landscape of embryonic stem cells.
The reduced total turnover observed for the K225R variant may therefore have resulted from the combined effects of slow turnover and enzyme stability in our time course experiments.
Caspase 8 mRNA turnover and protein stability in the presence or absence of cisplatin did not differ between both cell lines.
Ribosome footprinting has shown these proteins to be highly translated (Ingolia et al., 2009), and protein turnover experiments have shown them to be highly stable (Belle et al., 2006); thus, it is possible that their overabundance may result from the combination of the dynamics of protein biogenesis, protein turnover, and mRNA stability.
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