IFN γ induces TNF production, which in turn upregulates adhesion molecules on brain endothelial cells, leading to an increase in the adhesion of platelets and parasitized erythrocytes [ 26].
To summarize: (1) The cell-ECM bond deformation rate regulates the development of intracellular contractility, which in turn governs adhesion rupture dynamics; (2) Rac-dependent protrusion stabilization dynamics, also regulated by ECM stiffness, contributes to cell polarization; (3) Adhesion-dependent contractile forces must rupture rear adhesions to allow faster cell migration.
In turn, leukocyte adhesion upregulated endothelial CX3CL1, thereby triggering microglia trafficking to the injured site.
Enhanced cytokine secretion within the pleural space may in turn upregulate adhesion molecule expression and the synthesis of extracellular matrix constituents by pleural mesothelial cells.
Furthermore, we observed both an increase in ICAM-1 and VCAM-1 expression that induced, in turn, the adhesion of monocytes and lymphocytes at EC level promoting the formation of the atherosclerotic lesion [ 46].
These mechanotransduction pathways establish positive feedback loops in which integrin engagement activates actomyosin CSK contractility, which in turn reinforces adhesions.
Temporal cues such as systemic steroid signalling via differentially expressed miRNAs regulate a spatially distributed signalling factor that in turn modulates cell adhesion, putting differential cell adhesion as a key player in fine-tuning the fidelity of neuronal cell differentiation.
Thus, it is reasonable to deduce that PSC-SN-promoted trans-migration of cancer cell by providing adhesive molecule(s) to the interface of inserts, which in turn facilitated cell adhesion and then accelerated the motility.
Different electrode materials have different microscopic surface structure and conductivity, which in turn affects the adhesion of specific microbes (Rabaey et al. 2004Zhou et al. 2011).
The innovative concept is based on a MINUSHEET® tissue carrier, which enables the researcher to apply individually selected biomaterials promoting in turn optimal cell adhesion.
