Rather than being a constitutive mark of transcription, H3K4me2 may be implicated in fine tuning of tissue-specific expression, as recently reported in mammals (Pekowska et al, 2010).
However, they do contribute to the fine tuning of the tissue specific patterns of expression, extracellular signaling, overall promoter activity and chromatin modifications.
The, concomitant tissue- and time-specific activation of both, the wnt-signalling and the TGF-β Smad2/Smad3-pathway, is indicative for a synergistic involvement of both pathways in the fine tuning of neuronal tissue regeneration beyond a merely neuroprotective function of TGF-β.
Similarly, there has not yet been any physiological identification of crustacean neurons that are tuned to tissue damage.
With solder science solidifying and the laser technology tuning up, proponents of tissue welding are upbeat.
Nociceptors are sensory neurons that are tuned to tissue damage.
It becomes highly desired to understand how various nanofibrous matrices regulate skin cell behaviors and intracellular signaling pathways, important to tuning the functionality of tissue-engineered skin grafts and affecting the wound healing process.
These platforms have an immense potential in the field of tissue regeneration; by tuning the specific therapeutic molecule to the tissue of interest and by utilizing different collagen-based scaffolds, similar systems can be developed for enhancing the healing of a diverse range of tissues and organs.
The overall signal imparted by neurotrophins through Trk receptors' catalytic activity is compounded by tropic, trophic, and differentiation-inducing responses that jointly ensure the structural and functional tuning of responding cells and tissues.
Differences in Tex19 and Sectm1 expression may be associated with specific tuning of TE activity control across tissues and species.
The tissue-dependent tuning of network parameters can, therefore, result in widely different consequences of removing both dx and Su(dx) function, and a counterintuitive functional redundancy between dx and Su(dx) can emerge from the architecture of the network in which these genes participate.
