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PTMs act as a mechanism for precise tuning of the function(s) of proteins, typically by inducing conformational changes that subtly or dramatically alter the overall tertiary structure.
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The fine tuning of the AR function is regulated by two polymorphic sequences in the transactivating part of the receptor, namely, polyglutamine-encoding CAG repeats and polyglycine-encoding GGN triplets (Gao et al. 1996; Tut et al. 1997).
The target resolution would be achieved via careful tuning of the reconstruction function of HKS with the p e,e′K+ Λ,Σ0 and 12C (e,e′K+ 12Λ Bg.s.s
The individualization is achieved either by tuning the cost function, based on few well known clinical parameters (MPC1) or through the use of an individual model obtained via system identification techniques and an optimal tuning of the cost function based on real-life experiments (MPC2).
Since mutation of Siglecg increases the titer of anti-DNA antibodies [24] and since deletion of Shp1 in B cells causes autoimmune diseases [7], the balance of the Siglecg signaling will likely be important in the proper tuning of the B1a function in innate immunity against infection vs. autoimmune side effect.
Tuning of the ILD functions was measured for non-monotonic functions as the width of the ILD function and for monotonic ILD functions as the 80% dynamic range, and introducing background could affect these metrics.
Online tuning of the membership functions and control rules of fuzzy controller is carried out using simulated annealing (SA) to obtain improved performance by minimizing the error function.
In the proposed method, for achieving the desired level of robust performance, exact tuning of the membership functions is very important.
Potential differences in transparency approaches can be easily adjusted by fine tuning of the transfer-function.
After tuning of the initial reconstruction function generated from the measured map, the estimated HKS momentum resolution was 2.2×10−4 (FWHM).
Optimal tuning of the input-output function requires that it be positioned so as to minimize the information loss.
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