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Dormancy is an important physiological state during tumour development.
The time for tumour development following injection ranges from three months to three years.
Shankaran, V. et al. IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity.
Pathological characteristics of human cholangiocarcinoma include infiltrating inflammatory and immune cells that participate in tumour development.
Shankaran, V. et al. IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity.
By contrast, mice deficient in TRM formation were more susceptible to tumour development.
Wang, Q. et al. Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development.
TRIM24 binds chromatin and oestrogen receptor to activate oestrogen-dependent genes associated with cellular proliferation and tumour development.
For example, as described previously, some miRNAs are capable of regulating cancer-associated genes in ways that facilitate tumour development.
And using immunosuppressants to prevent rejection can cause unpleasant side effects, including a risk of promoting tumour development.
Thus higher levels of Foxp3+ Tregs correlate with more rapid tumour development in both control and Krt76−/− mice.
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