When melanomas with intermediate Breslow's tumor thickness were compared to thick primary lesions, a substantial (nearly 70-fold) decrease in CST6 gene expression was observed.
We sought to determine the relationship of tumor thickness to clinical and histopathologic parameters in laryngeal cancer.
Table 1 Breslow's tumor thickness Stage Depth I Tumor with ≤1.0 mm IIA 1.01 2.0 mm IIB 2.01 4.0 mm III 4.0 mm ≤ tumor depth.
Age, sex, tumor thickness, ulceration and location and cytoplasmic Skp2 expression were included in the regression model.
Cytoplasmic Skp2 expression correlated with AJCC stages (I vs II IV, P<0.001), tumor thickness (≤2.00 vs >2.00 mm, P<0.001) and ulceration (P = 0.005).
In primary melanoma patients, age, tumor thickness, ulceration and cytoplasmic Skp2 expression were all significantly associated with both overall and disease-specific survival (Table 2).
bBreslow vertical tumor thickness.
Clark's level, tumor thickness and mitotic rate were also determined.
Thus, we did not evaluate the tumor thickness.
Moreover, no differences were observed when comparing radial (tumor thickness < 1 mm) and vertical (tumor thickness ≥ 1 mm) growth phase tumors.
Vertical tumor thickness measurements of both methods were compared with histopathological assessments.
