Sentence examples for tumor substrate from inspiring English sources

We accounted for this behavior by limiting the amount of bacteria that can consume the tumor substrate, which effectively limits plasmid-containing bacterial growth and allows luciferase decay to dominate.

Both populations grow exponentially for 24 h until available nutrients become limiting, a process modeled by including a finite quantity of tumor substrate that is consumed according to Michaelis Menten kinetics (21).

As a consequence of mitochondrial dysfunction, cells are chronically subjected to a pro-oxidative environment [ 6], that is associated with tumor invasiveness [ 7], changes in tumor substrate metabolism [ 8], a lower concentration of anti-oxidant enzymes in tumor cells [ 9, 10], and increased production or reduced clearance of ROS [ 11].

We study the effects of two parameters on tumor morphology: a diffusion-limitation parameter defined as the ratio of the tumor-substrate consumption rate to the substrate-transport rate, and the tumor-TM surface tension.

While toxicity is likely to be the primary cause of the ineffectiveness of verapamil to improve the sensitivity of tumors to substrate drugs, our studies show that modification of doxorubicin distribution in tumors might be an additional cause of their failure to improve tumor response to chemotherapy.

In this report, we have developed a cathepsin-targeted, tumor-selective substrate probe 6QCNIR (9) that is compatible with existing clinical instrumentation for use in fluorescence image guided surgery.

TM far from the tumor still produces substrate, but the substrate is essentially exhausted at the tumor surface.

At the molecular level, MLN4924 inhibits Cullin RING E3 ligases (CRLs) by cullin deneddylation, causing accumulation of RhoA at an early stage to impair angiogenic activity of vascular endothelial cells and subsequently DNA damage response, cell cycle arrest and apoptosis due to accumulation of other tumor-suppressive substrates of CRLs.

Tumor cells absorb substrate at their respective centers of mass.

Intra venous administration of substrates avoids the constraints/requirements of knowing a priori where the expression will be observed, which confounds many existing in vivo imaging approaches to β-gal activity based on direct intra tumor injection of substrate.

Adding to the utility of these models, primary tumors are used as substrate to generate tumor-derived cell lines that maintain much of the biology of the original tumors, and retain key alleles of interest (Martin et al., 2013).