Exact(8)
As a result, they say, smokers would have fewer tar deposits in the larger lung tubes, accounting for the lower tumor rate there.
Tumor rate constant of [11C]erlotinib influx, i.e., K1, showed a trend towards positive correlation with TBF(E−) and TBF(E+); however, this was not statistically significant (r s = 0.714, P = 0.058 and r s = 0.405, P = 0.327, respectively, see Fig. 3c) (see Additional file 1: Table S4 for detailed results).
Lung tumor rate and age of onset are summarized in Figure 1.
Overall lung tumor rate was 23.1% (65/281) and 11.6% (22/189) in the transgenic and non-transgenic mice, respectively (Fisher's exact test p = 0.01).
Peak differences in tumor rate between the transgenics and non-transgenic mice occurred during the age of 13 21 months (OR: 3.64 p<0.01).
Interestingly, the tumor rate differences observed between the transgenics and the non-transgenic counterparts beginning at 13 months equalizes after 22 months, suggesting that the genome instability associated with senescence [55], [56] is diluting any difference that the transgene effect could produce.
However, the transgenic mice had a significant higher lung tumor rate than their non-transgenic counterparts during the age of 13 21 months, suggesting an age-related shift in lung tumor formation induced by the lung-specific expression of the human mutant p53.
23 Other clinical outcomes were also evaluated, ie, biochemical failure rate, death from tumor rate, and number of patients with adverse events (gastrointestinal and genitourinary, grade ≥ 2).
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