It was a rough and tumble time in Berlin, after the first world war and before the second, when politicians were fighting for power, and citizens fighting for something to believe in.
To account for this, several studies have considered the possibility of extended tumbling times [ 24, 26- 28].
Pioselli et al. (2011) observed significant differences in myofibrillar muscle protein composition of the exudates when using different salt concentrations and tumbling times.
In particular, we concentrate on the linear and adaptive responses to stimuli and analyse the chemotactic performance of these under a range of system parameters and tumbling times.
While this assumption is consistent with observations from E. coli [ 1], it is not expected that tumbling times are or have been always short in all bacteria.
With the domain-specific overall tumbling times set, we were able to fit the site-specific side-chain internal motion parameters, SAXIS2 and τe.
For example, tumbling times can be longer (i.e. smaller β) in bacteria with unidirectional motors, where a "tumble effect" results from the stopping or slowing of the motor(s) [ 29, 30].
Optimisation of response parameters for high CP showed that while the latter response type gives the highest CP in such low sensitivity regime, both types of response dynamics are characterised by long tumbling times (high λ).
It is possible that such intermediary systems had response dynamics as described here, e.g. adaptive dynamics with long tumbling times The alternative molecular route to achieving a transition between linear and adaptive responses would be to combine the output of two distinct systems with such responses.
Recent design of responsive gadolinium-based T1 agents has made interesting progress, with the development of novel complexes which sense their chemical environment through changes in the coordination of water molecules, the molecular tumbling time or the number of metal centres.
