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The dependence between the local concentration of attractant (A x)) and tumble rate (i.e. αR and αL) is characterised by three adjustable parameters, the basal tumbling rate α0, the signal gain λ, and the rate of exiting the tumbling state β (Table 1).
"It would be prudent to wait a little longer and monitor the tumble rate to see whether there's any attempt to stabilise it".
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With nanocrystalline specimens, the tumbling rate could be much less and stabilization might be unnecessary.
One way to alleviate this problem is to increase the effective tumbling rate by reducing the viscosity of the solvent.
Cyclic and acyclic polyaminocarboxylate gadolinium complexes, especially those have favourable water exchange and tumbling rate for relaxation, have been reported to improve relaxivity and specificity.
Filtered spectra (also referred to as edited spectra) based on specific NMR pulse sequences enabled selective suppression of signals modulated by intrinsic metabolites properties, such as molecular tumbling rate, diffusivity, hydrodynamic radius, and aggregation extent [31, 34].
Fluorescence anisotropy, based on the property of fluorescent molecules to retain the polarization of the excitation light, reflects the tumbling rate of molecules in solution.
The tumbling probability is modulated by a negative adaptive response; a step increase in attractant concentration results in a transient decrease in tumbling rate.
Peak broadening in the BiNP spectrum may be indicative of a slower tumbling rate of the organic molecules in solution when adhered to large inorganic nanoparticles.
Previously, we developed contrast agent PA conjugates for MRI and observed that these compounds exhibited enhanced image contrast due to their slow molecular tumbling rate.
This local motion reduces the effective rotational tumbling rate and therefore lowers relaxivity, as has been shown for other liposomal Gd-chelates [50].
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