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One possible explanation for this difference is that in the mismatch-deficient M. tuberculosis, selection against unstable sequences is stronger than in E. coli, and that this results in a stronger stabilization of the genome by context-dependent codon choice.
As a consequence of this study, numerous articles appeared in regional and national newspapers in The Netherlands in which the concern was expressed that mycobacterial lymphadenitis in children is a form of 'bird tuberculosis' (selection of newspaper articles: [ 4– 8]).
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By sequencing widely at multiple gene loci around the chromosome in a population sample of M. tuberculosis isolates, selection bias is avoided and all neutral variation within the sequenced regions will be identified.
It has been speculated that genetic variants enhancing resistance to tuberculosis underwent positive selection and provide the genetic basis for RA susceptibility today [9].
Previous treatment mismanagement is the probable cause of M. tuberculosis drug-resistance selection in most of these patients.
The use of fluoroquinolones (FQs) to treat lower respiratory tract infections (LTRI) other than tuberculosis (TB) allows selection of FQ-resistant TB when TB is misdiagnosed.
Text Box 1 describes how SACIDS's selection of tuberculosis (TB) as a priority disease reflects not only SACIDS's focus on One Health, given the potential spread of TB between animals and humans, but also seeks to enhance the effectiveness of already existing surveillance systems.
Drug resistance in M. tuberculosis arises through the selection of spontaneous mutations by inadequate therapy.
Improvement in tuberculosis treatment regimens requires selection of antibiotics and dosing schedules from a large design space of possibilities.
The dN/dS values were less than 1 for all 7 isolates (range from 0.608885 to 0.637365), supporting the notion that M. tuberculosis genomes undergo purifying selection.
To the final model, predictors were selected by forcing all those variables that were significant in pulmonary tuberculosis, and from other variables selection was by forward stepwise method.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com