Sentence examples for tuberculosis pathogenicity from inspiring English sources

These targeted genes are important to M. tuberculosis pathogenicity during infection.

Characterising the changing physiological predicament of distinct M. tb populations during infection will help expose the fundamental biology of M. tb highlighting mechanisms that influence tuberculosis pathogenicity.

This indicates that mycobacterial sodC is not essential for intracellular growth within macrophages and does not contribute to M. tuberculosis pathogenicity in the guinea-pig.

Third, because our study did not include pan-susceptible or isoniazid-monoresistant strains, we cannot comment directly on MDR M. tuberculosis pathogenicity relative to these groups.

As the acquisition of such enzymes can serve to modify ancestral compounds, a future challenge will be to identify the substrates of these enzymes and determine the role of the newly synthesized compounds in M. tuberculosis pathogenicity.

Enzymes of central carbon metabolism are essential mediators of Mycobacterium tuberculosis (Mtb) physiology and pathogenicity, but are often perceived to lack sufficient species selectivity to be pursued as potential drug targets.

The virulence factors explored in this study, the PE/PPE (proline-glutamate/proline-proline-glutamate motif) genes, mammalian cell entry (mce) operons and the mycobactin cluster, were chosen based on studies into M. tuberculosis and M. avium pathogenicity.

Despite their different tropisms, phenotypes and pathogenicities, M. tuberculosis complex (MTC) strains are highly clonal: their nucleotide sequences are 99.9% identical and 16S rRNA sequences do not differ between MTC members, with the exception of M. canetti.

These results suggest that while some genes acquired by horizontal transfer are necessary for full virulence, others may represent genes that were important at earlier stages in the evolution of slow-growing mycobacterial pathogens but are apparently dispensable for the specific pathogenicity of M. tuberculosis.

Although NTM are not obligate pathogens, they share the features of hardiness, hydrophobicity, aerosolization, and intracellular pathogenicity, with M. tuberculosis [2].

This is why it is very important to study in detail the development of pathogenicity of M. tuberculosis so that an emergence of new mycobacterial pathogens will not catch us unaware.