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A tuberculosis pathogen is a physical entity.
In 1882, Robert Koch discovered another microorganism during his observations using light microscopy that is now recognized as an actinobacterium: the tuberculosis pathogen Mycobacterium tuberculosis [16].
In 1943, Waksman again received attention, this time due to his greatest discovery: the antibiotic streptomycin isolated from Streptomyces griseus is effective against the tuberculosis pathogen [19].
Persistence and slow growth are clinically important states of the M. tuberculosis pathogen.
Because the tuberculosis pathogen is a respiratory agent, mucosal vaccination is well suited to initiate both the mucosal and systemic immune responses.
Since the tuberculosis pathogen is an airborne bacterium, the organism's immune response, both mucosal and systemic, can be induced via mucosa of the warm-blooded hosts.
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Cepheid's GeneXpert, for example, is an automated device for polymerase chain reaction (PCR) with special sample preparation cartridges for tuberculosis pathogens, MRSA or group B streptococci.
A previously unidentified Mycobacterium tuberculosis complex pathogen has emerged in banded mongooses (Mungos mungo) in Botswana; we named the pathogen mongoose bacillus, or M. mungi sp. nov. This pathogen causes high mortality rates among banded mongooses that live in close association with humans because these animals live in human-made structures and scavenge human waste, including feces.
In studies with Mycobacterium tuberculosis, a pathogen that establishes long-term infection, Nod2 deficient mice showed decreased pro-inflammatory cytokine production in early stages of infection similar to what is seen with bacteria causing acute infection [23].
Given the significance of M. tuberculosis as pathogen, it is important to investigate whether the genome of this microorganism is biased towards stability or instability.
We identified a Mycobacterium tuberculosis complex pathogen, M. mungi sp. nov., as the causative agent among banded mongooses that live near humans in Chobe District, Botswana.
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