Before every game, he soaks in a hot tub, plays catch, then runs a little to break a sweat.
Hence, we hypothesized that TUB plays a role in modulating food intake.
Further studies will be needed to test whether, as in mice, human TUB plays a role in the trafficking of GPCRs to cilia and in the modulation of signaling by hypothalamic GPCRs involved in energy homeostasis.
You were in the tub though, playing naked.
A woman sitting above the tub starts playing a Tibetan singing bowl while singing operatically—her voice is beautiful but hinted at the uneasiness we were all feeling.
And I'm standing here in my Grade 5 classroom playing with a tub toy.
The merman-like emergence from yet another tub by Jonny Orsini, playing the love interest to Nathan Lane's closeted burlesque actor in "The Nance," seems to exist principally as the setup for a punch line about his natural endowments.
Both compartments are thought to participate in the transport of ciliary cargo [Nachury et al., 2010; Gilliam et al., 2012] and there is growing evidence that TUB and other TUB family members play a role in the delivery of G protein-coupled receptors (GPCRs) to cilia [Mukhopadhyay and Jackson, 2011; Sun et al., 2012].
In "Hot Tub Time Machine," Corddry, playing the guy in a group of friends, who, as he put it recently, is "an asshole, but he's our asshole," gets punched several times.
Such disturbance in the expression of different neuropeptides, caused by loss-of-function mutations in TUB, suggests it plays an important role in the system controlling the appetite and feeding behavior.
