Exact(1)
The TTG metric does have similar limitations as TSR, i.e. it is a constant value metric that is used to predict survival also at time points before the metric has occurred, and TTG may be the same value even for patients with vastly different tumour responses (i.e. the extent of tumour shrinkage is not considered).
Similar(59)
The red vs. green graphs show the biological coherence of opposing regulated gene clusters controlled by TSRs, i.e. gene clusters with positive vs. negative factor loadings.
The only other type I receptors except for BMPR-IA and BMPR-IB that activate SMAD1/5/8 (and therefore could potentially be activated via GDF-5 and BMP-2) are ActR-IC (also known as TSR-I), which within the BMP/GDF subgroup is highly specific for BMP-9 and BMP-10 [ 37], and ActR-I (also known as Alk2).
Structurally, CYR61 protein consists of an N-terminal secretory peptide followed by 4 conserved domains with sequence homologies to insulin-like growth factor-binding protein (IGFBP), von Willebrand factor C repeat (VWC), thrombospondin type I repeat (TSR), and a carboxyl-terminal (CT) domain that contains a cysteine knot motif [ 1].
In the human protein, the region lies in the thrombospondin type-I repeat (TSR) domain which binds to heparin sulphate proteoglycans on hepatocytes [47], [48].
HARP consists of two beta-sheet domains (N- and C-TSR) containing thrombospondin-I repeats, which are flanked by flexible lysine-rich N- and C-terminal tails.
Our data indicate that the type I repeat region (TSR) of TSP-1 is important to the biological effects of LAP.
Unlike ADAM proteins, ADAMTS proteinases possess a well-conserved thrombospondin type 1-like repeat (TSR), homologous to the type I repeats of thrombospondins 1 and 2 [ 14], between the disintegrin-like and cysteine-rich domain (CRD).
The other second-generation ALK inhibitors such as CH5424802, AP26113, ASP3026, X-396, and TSR-011 are undergoing phase I or II clinical trials [ 10].
The achieved results indicated that using date seed ash will improve TSR of limestone and siliceous mixtures (i.e. 12.65% and 20%, respectively).
The proposed rules call for companies to report their annual total shareholder return (TSR) over time, along with annual TSR figures for their peer group, and to describe the relationships between their TSR and their executive compensation and between their TSR and the TSR of their peers.
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