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The finding motivates the hypothesis that the different experimentally observed TSEs in homologous proteins and circular permutants may represent potentially available pathways to the wild-type protein.
Although there have been many studies on TSEs in mammalian species, little is known about TSE pathogenesis in fish.
However, it should be highlighted that on-going targeted and scanning surveillance for sheep and goat TSEs in EU member states has so far not identified any BSE in sheep [20], [21].
This panel of samples thus represents the molecular diversity of TSEs in small ruminants, especially with the three basic PrPres phenotypes possibly demonstrated by Western blot in natural scrapie.
Scrapie and CWD differ from other TSEs in that epizootics can be maintained by horizontal transmission, as well as being mediated by an environmental reservoir of infectivity [5], [6].
While the understanding of TSEs in cervids has made substantial progress during the past few years, the assessment and management of risks possibly emanating from prions in skeletal muscles of CWD-infected cervids requires further research.
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We note that Avestimehr and Tse in [23] studied the outage capacity of slow fading relay channels.
Vast quantities of sterols were indicated at up to 64 mg g-1 TSE in the permeable sandstones.
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