Sentence examples for tsc function from inspiring English sources

Loss of TSC function produces changes in dendritic architecture of hippocampal neurons and altered synaptic properties [2].

Loss of TSC function results in heightened mTOR activity and inappropriate LTP induction upon a single high frequency stimulation in slice experiments [55].

It is also not known if loss of signaling is as detrimental to neuronal development as inappropriately elevated signaling, such as occurs with loss of TSC function.

These reports are counter-intuitive, since the known pathway suggests that deletion of TSC function within the oligodendrocyte lineage should lead to hyperactivation of mTOR signalling.

Loss of TSC function and subsequent mTORC1 activation lead to ER-stress and activation of the unfolded protein response (UPR) [ 147].

This study reveals the existence of cross-talk mechanisms between TR3 and the TSC that function in the regulation of mTOR signalling and demonstrates a novel physiological function for TR3 that may qualify it as a clinical target for the treatment of cardiac hypertrophy.

Overexpression of Rheb activates the pathway independent of Tsc gene function [11] [13].

Evidence for these non-canonical TSC-Rheb functions includes reports of TSC2-independent functions of TSC1, Rheb-independent functions of the TSC1 TSC2 complex and TORC1-independent functions of Rheb.

Although epithelial malignancy is not a common feature of TSC, loss of function of TSC1 has been identified in UC [ 23, 51, 52].

Collectively, the detection of LOH in a proportion of OSCC samples coupled with reduced gene expression both at the RNA and protein levels indicates a loss of function of TSC genes, implicating their role as tumor suppressors in oral cancer for the first time.

We have used genetic mosaics to evaluate the function of Tsc-Rheb-Tor signaling in photoreceptor axon guidance.