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Exact(4)
The truncated part of the PTP domain aligns with ptpn22 in our phylogenetic tree (Fig. 1), and to ensure that this is a member of the NT4 class PTPs, we derived a phylogenetic tree with truncated PTP domains from several species corresponding to the available sequence in the zebrafish genome (Fig. 2).
The cDNA is most often a truncated, 3' part of the spliced gene.
Since DSP-2 is only expressed at very low levels in cardiac muscle and the fact that we found orthotopic DSP expression on immunohistopathology using an antibody recognizing the truncated part of DSP, we conclude that the truncated isoform was still incorporated into the desmosomes but lacked functional integrity eventually leading to the early onset of heart failure in the affected individual.
Digestion of the ligated DNA with Sfi I enzyme linearizes circular DNA composed of truncated 5' part of the insertion vector and a genomic fragment, and generates a unique overhang on the λ buffer of vector for ligating splinkerette adaptor.
Similar(56)
The truncated parts of the REP-1 molecule are shown in red.
It also contains 16 truncated parts of various CDS, including disrupted copies of soj and mob.
We used the annotation tool InterProScan (Quevillon et al. 2005) to determine if truncated parts of PTC alleles that are not targeted by nonsense-mediated decay or expanded parts of SCP alleles that are not targeted by nonstop decay contained any known sequence features or domains.
By scanning the corresponding genome sequences using Artemis, we found some of the truncated parts of the FBG domain exist in the genome in close relation to the annotated fragment, suggesting that the truncation probably was a missannotation of the genome.
However, we found that two successive ORFs coded the N- and C-truncated parts of a putative full-length CNGC protein, respectively.
Three of four pARTs in subgroup 3 share A1pp domains [ 42], all members of subgroup 4 share WWE domains, and two members of subgroup 5 contain a second, truncated pART domain, reminiscent of the duplicated inactive ART domain found in the VIP2 and iota mART toxins [ 16, 23].
Disregarding the truncated part, all sequenced arrays of DTC84 elements are composed of an integer number of core repeats, all being positioned in the same orientation and forming the same junction with the microsatellite.
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