In a dose-dependent manner, truncated LL-37 analogs that contain the active domain amino acid sequences 17 32, but not residues 1 17 (inactive domain), neutralized endotoxin-free CPS immuno-stimulatory activity as assessed by release of pro-inflammatory mediators TNFα (Figure 3A) and IL-6 by target cells (Figure 3B).
This can include being bound, possibly bleeding, to a truncated tree in the manner of Goya's "Disasters of War" etchings.
Explaining his opposition to the NDAA, McCain criticized "the truncated process and partisan manner in which the Majority is forcing through a de facto repeal of a long-standing policy".
If the rat MVP repeat region sequence is truncated in an equivalent manner, the percentage of identical sites rises to 25% in both cases (148/588).
Gli-3 is degraded in a proteasome-dependent manner and its truncated form is a potential inhibitor of BMP-2 transcription.
In an analogous manner, N-terminal truncated mutants of CCL2 and CXCL8 effectively bound but failed to activate their receptors (Gong & Clark-Lewis, 1995; Moser et al, 1993).
204 Readers will likely draw weaker inferences from a trial that was truncated in a data-driven manner versus one that reports its findings after reaching a goal independent of results.
Because the sequences varied in length due to either incomplete genomic sequence availability or alternative splice variation, sequences were aligned in a pairwise manner and were truncated so that comparisons were made only between regions that were common to both sequences.
The literature contains several examples of splicing-truncated proteins functioning in this manner (Aasheim et al, 2000; Huang et al, 2006).
Nevertheless, to make our proposal comparable with OPTA and other previous works, we perform the comparison in an approximated manner by using a truncated Gaussian source.
