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Most in vitro dormancy models, using single stress factors, fail to generate a truly dormant Mtb population.
Since multiple-stress generates what appears to be truly dormant Mtb cells similar to those found in vivo, this in vitro dormancy model might be suitable for screening of drug candidates that can kill dormant Mtb.
An in vitro model that generates truly dormant Mtb cells is needed to elucidate the metabolic requirements that allow Mtb to successfully go through dormancy, identify new drug targets, and to screen drug candidates to discover novel drugs that can kill dormant pathogen.
Of these, negligible levels of truly dormant seeds remained as tested by tetrazolium (Table 4).
Of the wild-produced seeds, in comparison, 10 20% remained ungerminated and 4 8.8% remained truly dormant depending on the cross type (Table 4).
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Like all herpes viruses, such as the one that causes cold sores, varicella never truly goes away, but lurks dormant in the nervous system until some future reactivation event – often decades in the future.
But are those dormant abilities really useless and dormant?
"The relative size of the dormant 'zero sellers' tail was truly jaw-dropping," Page emphasised.
EAPG (p < 0.05) on entities of these two subnetworks clearly supported our view that the gene expression patterns in eco-dormant and swelling buds were truly different.
Third, we must establish a truly streamlined approach for those who hold excess or dormant spectrum to sell to those who need it and can commercialize it.
Some believed that the long dormant dao could be revived if one were truly a sage; Lo writes of Song Neo-Confucianists, "it is this self-image which explained their militant stand in relation to conventional ethics and scholarship".
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