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In consequence, our study did not address the true "sensitivity" of the methods used for detection but derived only relative sensitivities.
However, the true sensitivity of hub cultures to detect endoluminal infection is unknown.
It is therefore essential to estimate the true sensitivity of bacteriological culture when evaluating other diagnostic methods.
More problematic is the true sensitivity of culture, which is difficult to determine but may be low.
Culture is the leading investigation for patients with suspected infection from a wide range of pathogens, but ascertaining the true sensitivity of this test is difficult.
Furthermore, due to ethical considerations, conization of every woman is not possible and therefore the true sensitivity of the test cannot be determined.
Similar(31)
However, no histologic standard of reference was available to determine the true sensitivities of both methods.
The key findings of this study are that the true sensitivities of culture, MAT, and culture plus MAT are low.
It might be argued that the use of EIS as an adjunct merely improves the true sensitivity because of the increased number of biopsies taken.
However, accuracy of such strategy is controversial because true sensitivity and specificity of Gram's stain for diagnosis of VAP remain questionable.
This implies that when qPCR is conjunctively used with culture, sensitivity of detecting IPA could approach 100%, though much larger numbers of samples will be needed to define the true sensitivity and specificity of the qPCR assay.
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CEO of Professional Science Editing for Scientists @ prosciediting.com