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This may limit the generalizability of the findings, due to sampling bias and a lack of true representativeness.
While targeted recruitment will increase the numbers of participants in particular subgroups and allow for more detailed study of these individuals, true representativeness is unlikely to be achieved in any voluntary study.
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It is, however, difficult to assess true completeness, representativeness and accuracy without having access to linked data [ 32].
Hence, the 95% CI presented in this investigation may better reflect that of the actual landscape, containing more variables that make-up the complex landscape heterogeneity (i.e. improved representativeness), although this is only true for those pixels estimated using the correlation equations (86% of the EAM but only 52% of the study area).
First, they may be limited in their representativeness and may possibly underestimate the true magnitude of primary and acquired resistance, particularly in settings where concurrent tuberculosis and human immunodeficiency virus (HIV) infection is frequent or where patients with tuberculosis are commonly treated by private health providers [ 18].
It is true that qualitative research is not based on statistical representativeness.
Given the enforced lack of true random sampling, we cannot be sure of the statistical representativeness of our groups of interviewees.
Thus, the representativeness of our controls was reliable.
In order to verify the representativeness of the survey and to estimate the total or "true" MPS numbers reliably, the survey results were related to the data of the National Association of Statutory Health Insurance Physicians NASHIPP) [Kassenärztliche Bundesvereinigung (KBV)] [ 10].
For cohort studies, limited representativeness may mean that results cannot be assumed to be true for unsurveyed or underrepresented subsets of the population of interest; this was a key incentive in devising the xTEND study.
If this advocacy group claims, with reference to this PIA, that the regional public actually supports their agenda, this claim is only true if the organizers of this PIA ensured that there is some kind of representativeness relation between their sample and the regional public.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com