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These images were used to ensure that the MEG sensors selected were located above the true regions of interest.
If this was the case, we would not be capturing the true regions from which patients would present to a laboratory-linked hospital.
The flip side of this filtering was that true regions of alterations could be filtered out (as shown in the green area in Figure 1), leading to probably more false negatives.
We found that using a radius of 100 kb or 1 Mb led to true regions that covered a substantial portion of the genome in the cases where there were a large number of QTL.
We show that these regions contain fixed gene sets, rather than being true regions of genome plasticity, but two different types and several subtypes with partly diverging gene content can be distinguished.
Then we generated 1000 datasets composed by randomly chosen peaks, each containing the same number of regions with the same length (200 bps) and the same nucleotide distribution as true regions.
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The criterion of ER is based on the region of detected object (= true region) in ground-truth images such as Figure 10.
In practice, TFR remaps the spectral energy corresponding to a spectrogram cell into another time-frequency point, which is closest to the true region of support of the analyzed signal.
One might propose that a gene that is expressed at one point in the development of an early developing region may be expressed at later times in a later developing region, and not represent true region-specificity.
We define the true region to consist of all variants within the specified radius of any QTL (i.e., 10 kb here), and we define the neutral genome to be the rest of the genome (outside the true region).
When these data were applied to DT analysis in 2-dipole estimation, dipoles in the contralateral hemisphere were localized in a restricted true region while those in the ipsilateral hemisphere were scattered more widely.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com