While on the wane as a large-scale experimental technique, this tried and true methodology still retains usefulness and economy in large-scale replication and screening assays.
On the assumption that all null hypotheses are true, methodology that deals with FDR employs the likely calculation of Holm's procedure with more relaxed conditions for the compensating threshold; however, the FDR methodology is still stricter than the original tests without compensations.
In a 2006 paper about detector dogs, Richard Myers, a law professor at the University of North Carolina, summarized the lazy rhetoric that courts often use to avoid questioning supposedly tried-and-true methodologies: "The use of [insert technology here] is well-settled in the law of this [state/circuit] and we need not revisit it here".
In a 2006 paper about detector dogs, Richard Myers, a law professor at the University of North Carolina, summarized the lazy rhetoric that courts often use to avoid questioning supposedly tried-and-true methodologies: "The use of is well-settled in the law of this [state/circuit] and we need not revisit it here".
For example, researchers generally adopt "tried-and-true" methodologies from cDNA microarray technology for miRNA expression analysis, but the relatively small number of probes on miRNA microarrays may render these high-density approaches ineffective.
Despite of what it might seem obvious to most people, the industry still lacks the implementation of "true QbD" methodologies that start with the design of the product itself.
True, the methodology of particular studies may be challenged, and some of the figures arrived at may be disputed.
However, there might be no way to verify the correctness of the methods used as there is neither a true best methodology nor a true ranking of the Pareto optima.
Comparison between HaloCHIP-chip and ChIP-chip data reveal this to be true for both methodologies, indicating it is not a bias of the technology chosen.
In light thereof, several authors pointed to the lack of serious recent work on comparative methodology (Samuel, 2004, p. 35), regretting that true questions of methodology hardly ever rise (von Bar, 2004, p. 130) and complaining that attempts to develop even a moderately sophisticated method of comparison is exceedingly rare in comparative studies.
For this reason, all BISTI applications--or any that involve true biological computational methodology--will be reviewed by groups that contain "special expertise in the computer science and informatics areas," he says.
