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The original goal of True et al. was to identify a molecular correlate for Gleason patterns 3 and, if possible, the clinically most worrisome patterns 4 and 5.
We have previously mentioned that BRCA1 is a conspiquous biomarker arising from the analysis of True et al.'s dataset using our methods.
Another microarray dataset we have selected to evaluate for the relevance of transitions of Normalized Shannon Entropy and Statistical Complexity was contributed by True et al. [332] in 2006.
We thus turned our attention to these probes that have been annotated as "non-protein coding" and we highlight some of them that have very high correlation values with the Normalized Shannon Entropy in True et al's prostate cancer dataset.
For instance, on True et al's dataset, our unifying hallmark of cancer gives not only MAOA, which was already identified in the original publication, but also AMACR, CD40, CDK4, etc. are very important biomarkers for prostate cancer.
For each spot and in each channel (Cy3 and Cy5), True et al. substracted the median background intensity from the median foreground intensity, and subsequently the log ratios of cancer expression to benign expression were computed.
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As a cluster of papers in eLife and elsewhere make clear, this prediction looks to be coming true (Cong et al., 2013; Mali et al., 2013; Jinek et al., 2013).
In our specific application, aspatial models seem to perform as well as their more complex spatial counterparts; however, other studies have not found this to be true (Chaix et al. 2005a, 2005b; Takagi et al. 2012).
However, this is not generally true (Kempter et al. 2001; Izhikevich and Desai 2003; Morrison et al. 2007).
Euchromatic regions that are centromere- and telomere-proximal have reduced rates of crossing over (True, Mercer, et al. 1996), reduced polymorphism, and elevated divergence (fig. 1; Begun et al. 2007; Langley et al. 2012; Mackay et al. 2012).
1197), one of the most prominent of the twelfth-century theologians at the University of Paris, makes direct reference to the passage from James, distinguishing religion that is pure and true (munda et vera) from that which is vain and false (vana et falsa).
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